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KMID : 0371819770090010001
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Nuclear Engineering and Technology
1977 Volume.9 No. 1 p.1 ~ p.6
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A Simple Preparation of Monoiodobromosulfophthalein-^(131)I by Isotope Exchange for Medical Use
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Kim Jaerok
Kim Tae-Ho
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Abstract
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Monoiodobromosulfophthalein-131 I (MIBSP-131 I), one of the useful radioph-armaceuticals for liver function studies, has been prepared by a simple iso-tope exchange between the MIESP and the molecular iodine-131 I in phosphate buffer, pH 5.3.
The pooled cold MIBSP was prepared by a normal iodination of BSP using iodine monochloride, and separated from the iudination mixture by applying a Sephadex LH-20 chromatography.
At 100°C, the exchange rate was so fast that the reaction could be terminated in 5 min to show upto 95% yield. The final product could be obtained simply by further heating for about 5 min in a boiling water bath in the presence of a small amount of hydrogen peroxide, and subsequent pH adjust-ment and membrane filtration.
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KEYWORD
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